2024

Seah I, Goh D, Banerjee A, Su X.
Modeling inherited retinal diseases using human induced pluripotent stem cell derived photoreceptor cells and retinal pigment epithelial cells.
Front Med (Lausanne). 2024 Jul 1;11:1328474. doi: 10.3389/fmed.2024.1328474. PMID: 39011458; PMCID: PMC11246861.

Liu H, Wu C, Hu S, Leng B, Lou X, Liu Z, Su X, Huang D.
Lutein Modulates Cellular Functionalities and Regulates NLRP3 Inflammasome in a H₂O₂-Challenged Three-Dimensional Retinal Pigment Epithelium Model.
J Agric Food Chem. 2024 Jul 3;72(26):14701-14712. doi: 10.1021/acs.jafc.4c01537. Epub 2024 Jun 19. PMID: 38897610.

Loh WW, Lin Q, Zhao X, Su X, Loh XJ, Lim JYC.
Polyurea-urethane Temperature-responsive Hydrogels for Sustained Delivery of Anti-VEGF Therapeutics.
Chem Asian J. 2024 Jun 15:e202400453. doi: 10.1002/asia.202400453. Epub ahead of print. PMID: 38878271.

Arwani RT, Tan SCL, Sundarapandi A, Goh WP, Liu Y, Leong FY, Yang W, Zheng XT, Yu Y, Jiang C, Ang YC, Kong L, Teo SL, Chen P, Su X, Li H, Liu Z, Chen X, Yang L, Liu Y.
Stretchable ionic-electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers.
Nat Mater. 2024 Jun 12. doi: 10.1038/s41563-024-01918-9. Epub ahead of print. PMID: 38867019.

Wong WM, Tham YC, Simunovic MP, Chen FK, Luu CD, Chen H, Jin ZB, Shen RJ, Li S, Sui R, Zhao C, Yang L, Bhende M, Raman R, Sen P, Ghosh A, Poornachandra B, Sasongko MB, Arianti A, Chia V, Mangunsong CO, Manurung F, Fujinami K, Ikeda H, Woo SJ, Kim SJ, Mohd Khialdin S, Othman O, Bastion MC, Kamalden AT, Lott PWP, Fong K, Shunmugam M, Lim A, Thapa R, Pradhan E, Rajkarnikar SP, Adhikari S, Ibañez BMBI, Koh A, Chan CMM, Fenner BJ, Tan TE, Laude A, Ngo WK, Holder GE, Su X, Chen TC, Wang NK, Kang EY, Huang CH, Surawatsatien N, Pisuchpen P, Sujirakul T, Kumaramanickavel G, Singh M, Leroy B, Michaelides M, Cheng CY, Chen LJ, Chan HW.
Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases.
Asia Pac J Ophthalmol (Phila). 2024 Jan-Feb;13(1):100030. doi: 10.1016/j.apjo.2023.100030. Epub 2023 Dec 1. PMID: 38233300.

2023

Hu W, Zheng R, Feng Y, Tan D, Chan Chung-Tsing G, Su X, Kim JE
Impacts of regular consumption of grapes on macular pigment accumulation in Singapore older adults: a randomized controlled trial.
Food Funct. 2023 Sep 19;14(18):8321-8330. doi: 10.1039/d3fo02105j. PMID: 37605542.

⁂ Parikh BH, Blakeley P, Regha K, Liu Z, Yang B, Bhargava M, Wong DSL, Tan QSW, Wong CSW, Wang HF, Al-Mubaarak A, Chou C, Cheung CMG, Lim KL, Barathi VA, Hunziker W, Lingam G, Hu TX, Su X*.
Single-cell transcriptomics reveals maturation of transplanted stem cell-derived retinal pigment epithelial cells toward native state.
Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2214842120. doi: 10.1073/pnas.2214842120. Epub 2023 Jun 20. PMID: 37339216; PMCID: PMC10293804.

Kamarudin JBM, Sun B, Foo ASC, Lim XY, Judd H, Tan X, Tan XH, Razar RBBA, Liu M, Zhong J, Chua JJE, Ng CWQ, Goh JCH, Tan TZ, Parikh BH, Su X, Kumar AP, Ong WY, Yamaguchi N, Set SY, Yip GW, Zhang Y, Teh DBL.
SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy.
ACS Nano. 2023 Jun 27;17(12):11593-11606. doi: 10.1021/acsnano.3c01916. Epub 2023 Jun 12. PMID: 3730655

Wong WM, Sun W, Vyas C, Fong AHC, Chee CK, Su XY, Teo KY, Cheung CMG.
Analysis of the pachychoroid phenotype in an Asian population: methodology and baseline study population characteristics.
Br J Ophthalmol. 2023 May;107(5):698-704. doi: 10.1136/bjo-2022-322457. Epub 2023 Feb 21. PMID: 36810152.

Lenin RR, Koh YH, Zhang Z, Yeo YZ, Parikh BH, Seah I, Wong W, Su X*.
Dysfunctional Autophagy, Proteostasis, and Mitochondria as a Prelude to Age-Related Macular Degeneration.
Int J Mol Sci. 2023 May 15;24(10):8763. doi: 10.3390/ijms24108763. PMID: 37240109; PMCID: PMC10217992.

Wu D, Lim BXH, Seah I, Xie S, Jaeger JE, Symons RK, Heffernan AL, Curren EEM, Leong SCY, Riau AK, Lim DKA, Stapleton F, Ali MJ, Singh S, Tong L, Mehta JS, Su X, Lim CHL.
Impact of Microplastics on the Ocular Surface.
Int J Mol Sci. 2023 Feb 15;24(4):3928. doi: 10.3390/ijms24043928. PMID: 36835339; PMCID: PMC9962686.

2022

Zhang K, Liu Z, Lin Q, Boo YJ, Ow V, Zhao X, Wong DSL, Lim JYC, Xue K, Su X, Wu D, Loh XJ.
Injectable PTHF-based thermogelling polyurethane implants for long-term intraocular application.
Biomater Res. 2022;26(1):70. Published 2022 Dec 2. doi:10.1186/s40824-022-00316-z

Regha K, Bhargava M, Al-Mubaarak A, Chai C, Parikh BH, Liu Z, Wong CSW, Hunziker W, Lim KL, Su X.
Customized strategies for high-yield purification of retinal pigment epithelial cells differentiated from different stem cell sources.
Scientific Reports 12, 15563 (2022). https://doi.org/10.1038/s41598-022-19777-2

Lim SY, Wong WM, Seah I, Chan HW, Su X, Lingam G, Yuen YS.
Treat and extend regimen for diabetic macular oedema-a systematic review and meta-analysis.
Graefes Arch Clin Exp Ophthalmol. 2023 Feb;261(2):303-315. doi: 10.1007/s00417-022-05770-y. Epub 2022 Jul 30. PMID: 35906415.

⁂ Parikh BH, Liu Z, Blakeley P, Lin Q, Singh M, Ong JY, Ho KH, Lai JW, Bogireddi H, Tran KC, Lim JYC, Xue K, Al-Mubaarak A, Yang B, R S, Regha K, Wong DSL, Tan QSW, Zhang Z, Jeyasekharan AD, Barathi VA, Yu W, Cheong KH, Blenkinsop TA, Hunziker W, Lingam G, Loh XJ, Su X.
A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.
Nat Commun 13, 2796 (2022). https://doi.org/10.1038/s41467-022-30474-6

Wu KX, Yeo NJY, Ng CY, Chioh FWJ, Fan Q, Tian X, Yang B, Narayanan G, Tay HM, Hou HW, Dunn NR, Su X, Cheung CMG, Cheung C.
Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy.
BMC Biol  2022 Feb 15;20(1):47. doi: 10.1186/s12915-022-01244-z

Seah I, Goh D, Chan HW, Su X*.
Developing Non-Human Primate Models of Inherited Retinal Diseases
(Basel). 2022 Feb 14;13(2):344. doi: 10.3390/genes13020344

2021

Xinyi Su*, Wong Tien Yin
Revisiting the Alcohol Consumption association with Age-Related Macular Degeneration: What should we tell our Patients in 2021?”
Nature Communication
JAMA Ophthalmology 2021 Dec 1;139(12):1307-1308. doi:10.1001/jamaophthalmol.2021.4602

Tan TE, Fenner BJ, Barathi VA, Tun SBB, Wey YS, Tsai ASH, Su X, Lee SY, Cheung CMG, Wong TY, Mehta JS, Teo KYC.Gene-based Therapeutics for Acquired Retinal Disease: Opportunities and Progress.
Frontiers in Genetics 2021 Dec 7;12:795010. doi: 10.3389/fgene.2021.795010

⁂ Lin Q, Liu Z, Wong DSL, Lim CC, Liu CK, Guo L, Zhao X, Boo YJ, Wong JHM, Tan RPT, Xue K, Lim JYC, Su X*, Loh XJ.
High Molecular weight hyper-branched PCL-based thermogelling vitreous endotamponades.
Biomaterials 2021 Nov 17;121262. doi: 10.1016/j.biomaterials.2021.121262

⁂ Zhao X, Seah I, Xue K, Wong W, Tan QSW, Ma X, Lin Q, Lim JYC, Liu Z, Parikh BH, Mehta KN, Lai JW, Yang B, Tran KC, Barathi VA, Cheong KH, Hunziker W, Su X*, Loh XJ.
Anti-Angiogenic Nanomicelles for the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease.
Advanced Materials 2021 Nov 2;e2108360. doi: 10.1002/adma.202108360

Gautam P, Hamashima K, Chen Y, Zeng Y, Makovoz B, Parikh BH, Lee HY, Lau KA, Su X, Wong RCB, Chan WK, Li H, Blenkinsop TA, Loh YH.
Multi-species single-cell transcriptomic analysis of ocular compartment regulons
Nature Communication 2021 Sept 28;12(1):5675. doi: 10.1038/s41467-021-25968-8

⁂ Lingam S, Liu Z, Yang B, Wong W, Parikh BH, Ong JY, Goh D, Wong DSL, Tan QSW, Tan GSW, Holder GE, Regha K, Barathi VA, Hunziker W, Lingam G, Zeng X, Su X*.
cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates.
Stem Cell Res Therapy. 2021 Aug 19;12(1):463.  doi 10.1186/s13287-021-02539-8

Retinal progenitor cells derived from RxCell induced pluripotent stem cells (iPSCs) can mature into retina photoreceptors after transplantation into the preclinical models, enabling restored vision

Selection of some news websites reporting on the article:

• Ophthalmology Times
• Science Daily
• Yong Loo Lin School of Medicine

Lingam G, Sen AC, Lingam V, Bhende M, Padhi TR, Xinyi S*.
Ocular coloboma- a comprehensive review for the clinician.
Eye (Lond) 2021 Aug;35(8):2086-2109. PMID 33746210. doi: 10.1038/s41433-021-01501-5

⁂ Liu Z, Ilmarinen T, Tan GSW, Hongisto H, Wong EYM, Tsai ASH, Al-Nawaiseh S, Holder GE, Su X, Barathi VA, Skottman H, Stanzel BV.
Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model.
Stem Cell Res Ther. 2021 Jul 27;12(1):423. doi: 10.1186/s13287-021-02395-6

⁂ Seah I, Liu Z, Soo Lin Wong D, Wong W, Holder GE, Amutha Barathi V, Lingam G, Su X, Stanzel BV.
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases.
J Vis Exp. 2021 Jun 14;(172). doi: 10.3791/62638

⁂ Liu Z, Parikh BH, Tan QSW, Wong DSL, Ong KH, Yu W, Seah I, Holder GE, Hunziker W, Tan GSW, Barathi VA, Lingam G, Stanzel BV, Blenkinsop TA, Su X.
Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression.
Stem Cell Reports. 2021 Feb 9;16(2):237-251. doi: 10.1016/j.stemcr.2020.12.007

Selection of reports on multiple scientific news websites for this article.

• SciTechDaily
• Fierce Biotech
• Chinese media

Article was also featured on the cover of the Feb 2021 hardcopy issue of Stem Cell Reports. Cover image as seen on left.

2020

Yonova-Doing E, Zhao W, Igo RP Jr, Wang C, Sundaresan P, Lee KE, Jun GR, Alves AC, Chai X, Chan ASY, Lee MC, Fong A, Tan AG, Khor CC, Chew EY, Hysi PG, Fan Q, Chua J, Chung J, Liao J, Colijn JM, Burdon KP, Fritsche LG, Swift MK, Hilmy MH, Chee ML, Tedja M, Bonnemaijer PWM, Gupta P, Tan QS, Li Z, Vithana EN, Ravindran RD, Chee SP, Shi Y, Liu W, Su X, Sim X, Shen Y, Wang YX, Li H, Tham YC, Teo YY, Aung T, Small KS, Mitchell P, Jonas JB, Wong TY, Fletcher AE, Klaver CCW, Klein BEK, Wang JJ, Iyengar SK, Hammond CJ, Cheng CY.
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract.
Commun Biol. 2020 Dec 11;3(1):755. doi: 10.1038/s42003-020-01421-2

Seah I, Zhao X, Lin Q, Liu Z, Su SZZ, Yuen YS, Hunziker W, Lingam G, Loh XJ, Su X.
Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases.
Eye (Lond). 2020 Aug;34(8):1341-1356. doi: 10.1038/s41433-020-0770-y. Erratum in: Eye (Lond). 2020 May 22

Wong CW, Foo LL, Morjaria P, Morgan I, Mueller A, Davis A, Keys D, He M, Sankaridurg P, Zhu JF, Hendicott P, Tan D, Saw SM, Cheng CY, Lamoureux EL, Crowston JG, Gemmy Cheung CM, Sng C, Chan C, Wong D, Lee SY, Agrawal R, Hoang QV, Su X, Koh A, Ngo C, Chen H, Wu PC, Chia A, Jonas JB, Wong TY, Ang M.
Highlights from the 2019 International Myopia Summit on ‘controversies in myopia’.
Br J Ophthalmol. 2020 Aug 18:bjophthalmol-2020-316475. doi: 10.1136/bjophthalmol-2020-316475

Seah I, Su X, Lingam G.
Revisiting the dangers of the coronavirus in the ophthalmology practice.
Eye (Lond). 2020 Jul;34(7):1155-1157. doi: 10.1038/s41433-020-0790-7. Epub 2020 Feb 6.

Gopal L, Xinyi S.
Commentary: All India Ophthalmological Society members’ survey: Practice pattern of intravitreal anti-vascular endothelial growth factor injection.
Indian J Ophthalmol. 2020 Jun;68(6):1100-1101. doi: 10.4103/ijo.IJO_16_20

Wong WM, Chee C, Bhargava M, Chai C, Lin H, Zhao P, Ariadarma Mangunkusumo E, Naing T, Yuen YS, Wong TY, Su X, Lingam G.
Systemic Factors Associated with Treatment Response in Diabetic Macular Edema.
J Ophthalmol. 2020 Mar 19;2020:1875860. doi: 10.1155/2020/1875860.

Xue K , Liu Z , Jiang L , Kai D , Li Z , Su X , Loh XJ .
A new highly transparent injectable PHA-based thermogelling vitreous substitute.
Biomater Sci. 2020 Feb 4;8(3):926-936. doi: 10.1039/c9bm01603a

2019

Xue K, Zhao X, Zhang Z, Qiu B, Tan QSW, Ong KH, Liu Z, Parikh BH, Barathi VA, Yu W, Wang X, Lingam G, Hunziker W, Su X, Loh XJ.
Sustained delivery of anti-VEGFs from thermogel depots inhibits angiogenesis without the need for multiple injections.
Biomater Sci. 2019 Nov 1;7(11):4603-4614. doi: 10.1039/c9bm01049a. Epub 2019 Aug 22.

Liu Z, Liow SS, Lai SL, Alli-Shaik A, Holder GE, Parikh BH, Krishnakumar S, Li Z, Tan MJ, Gunaratne J, Barathi VA, Hunziker W, Lakshminarayanan R, Tan CWT, Chee CK, Zhao P, Lingam G, Loh XJ, Su X.
Retinal-detachment repair and vitreous-like-body reformation via a thermogelling polymer endotamponade.
Nat Biomed Eng. 2019 Aug;3(8):598-610. doi: 10.1038/s41551-019-0382-7. Epub 2019 Apr 8.

2017

Chan SY, Chan BQY, Liu Z, Parikh BH, Zhang K, Lin Q, Su X, Kai D, Choo WS, Young DJ, Loh XJ.
Electrospun Pectin-Polyhydroxybutyrate Nanofibers for Retinal Tissue Engineering.
ACS Omega. 2017 Dec 31;2(12):8959-8968. doi: 10.1021/acsomega.7b01604. Epub 2017 Dec 14.

2016

Su X, Tan QS, Parikh BH, Tan A, Mehta MN, Sia Wey Y, Tun SB, Li LJ, Han XY, Wong TY, Hunziker W, Luu CD, Owada Y, Barathi VA, Zhang SS, Chaurasia SS. Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina.
Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3397-408. doi: 10.1167/iovs.15-18542

2015

Su X, Tan MJ, Li Z, Wong M, Rajamani L, Lingam G, Loh XJ.
Recent Progress in Using Biomaterials as Vitreous Substitutes.
Biomacromolecules. 2015 Oct 12;16(10):3093-102. doi: 10.1021/acs.biomac.5b01091. Epub 2015 Sep 18. 

2014

Liao J, Su X, Chen P, Wang X, Xu L, Li X, Thean L, Tan C, Tan AG, Tay WT, Jun G, Zheng Y, Chew M, Wang YX, Tan QS, Barathi VA, Klein BE, Saw SM, Vithana EN, Tai ES, Iyengar SK, Mitchell P, Khor CC, Aung T, Wang JJ, Jonas JB, Teo YY, Wong TY, Cheng CY.
Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
Hum Mol Genet. 2014 Nov 15;23(22):6119-28. doi: 10.1093/hmg/ddu315. Epub 2014 Jun 20.

Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, Wong TY.
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.
Lancet Glob Health. 2014 Feb;2(2):e106-16. doi: 10.1016/S2214-109X(13)70145-1. Epub 2014 Jan 3.

2009

Ayoub N, Rajendra E, Su X, Jeyasekharan AD, Mahen R, Venkitaraman AR.
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.
Curr Biol. 2009 Jul 14;19(13):1075-85. doi: 10.1016/j.cub.2009.05.057. Epub 2009 Jun 18.

2008

Su X, Bernal JA, Venkitaraman AR.
Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51.
Nat Struct Mol Biol. 2008 Oct;15(10):1049-58. doi: 10.1038/nsmb.1490. Epub 2008 Sep 14.

2003

Kadam-Pai P, Su XY, Miranda JJ, Soemantri A, Saha N, Heng CK, Lai PS. Ethnic variations of a retinoblastoma susceptibility gene (RB1) polymorphism in eight Asian populations.
J Genet. 2003 Apr-Aug;82(1-2):33-7. doi: 10.1007/BF02715879